Abstract
ABSTRACTObjective: To characterize the number and methods of closure of Persistent Ductus Arteriosus (PDA) over a span of 16 years in a third level maternity hospital.Methods: Retrospective study of neonates born between January 2003 and Deccember 2018, who underwent ductus arteriosus closure by pharmacological, surgical and/or transcatheter methods. Gestational age, birth weight, number and methods of closures per year were evaluated. The success rate of the pharmacologic method was calculated, as well as the mortality rate. The association between mortality and birthweight, treatment used and treatment failure was explored.Results: There were 47,198 births, 5,156 were preterm, 325 presented PDA and 106 were eligible for closure (median gestational age - 27 weeks, birthweight <1000 g - 61%). Frequency of PDA closure decreased during the study period, especially starting in 2010. Success rate with pharmacologic treatment was 62% after the first cycle and 74% after the second. After drug failure, 12 underwent surgical ligation and two underwent transcatheter closure. Exclusive surgical ligation was indicated in four infants. Ibuprofen replaced indomethacin in 2010, and acetaminophen was used in three infants. Among the 106 infants, hospital mortality was 12% and it was associated with birthweight <1000 g (13/65 <1000 vs. 0/41 >1000 g; p=0.002) and with failure in the first pharmacologic treatment cycle (13/27 with failure, vs. 0/75 without failure; p<0.001).Conclusions: The national consensus published in 2010 for the diagnosis and treatment of PDA in preterm infants led to a decrease in the indication for closure. Pharmacological closure was the method of choice, followed by surgical ligation. Birthweight <1000 g and first cycle of pharmacologic treatment failure were associated with higher mortality.
Highlights
Exclusive surgical ligation was indicated in four infants
The national consensus published in 2010 for Conclusões: Consenso nacional de 2010 para diagnóstico e the diagnosis and treatment of Persistent Ductus Arteriosus (PDA) in preterm infants led to a tratamento do canal arterial nos prematuros levou à diminuição do decrease in the indication for closure
A total of 4,341 newborns were admitted to the UAPD of the maternity hospital, and, among them, 2,767 (64%) were premature infants
Summary
Retrospective study of neonates born between January de 2003 a 31 de dezembro de 2018 submetidos a fechamento and Deccember 2018, who underwent ductus arteriosus do canal arterial por métodos farmacológico, cirúrgico e/ou closure by pharmacological, surgical and/or transcatheter percutâneo. Avaliaram-se idade gestacional, sexo, peso ao methods. Gestational age, birth weight, number and methods nascimento, número de fechamentos por ano e método utilizado. The success rate of the Aferiram-se as taxas de sucesso de método farmacológico e pharmacologic method was calculated, as well as the mortality de mortalidade e sua associação com peso ao nascer, fármaco rate. The association between mortality and birthweight, treatment utilizado e insucesso do fechamento. Resultados: Verificaram-se 47.198 recém-nascidos, 5.156 prematuros, Results: There were 47,198 births, 5,156 were preterm, 325 presented dos quais 325 com canal arterial patente, sendo 106 com indicação
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
