Patellins 1-6 and Trunkamide A: Novel Cyclic Hexa-, Hepta- and Octa-peptides From Colonial Ascidians, Lissoclinum sp.

Abstract

Patellins 1-5 have been isolated from the colonial ascidian Lissoclinum patella from Viti Levu , Fiji. Patellins 1 and 2 are cyclic hexapeptides, while patellins 3-5 are cyclic octapeptides. Two of these peptides ( patellins 3 and 5), a new cyclic octapeptide ( patellin G), a new cyclic heptapeptide ( trunkamide A), and the known metabolite lissoclinolide have also been isolated from a Lissoclinum sp. collected on the Great Barrier Reef, Australia. All structures were determined by high-field n.m.r. and mass spectroscopic methods, and by h.p.l.c . Analysis of the constituent amino acids after hydrolysis of the peptides and derivatization according to Marfey's procedure.