Abstract
Background and Objective: Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints. And KOA is common in the elderly and seriously affects the exercise function and physical health of patients. This study aimed to explore the curative effects of patellar inward pushing method (PIPM) on KOA. Methods: In this study, we established rabbit animal models of KOA for the research by using the New Zealand white rabbits. A total of n=30 rabbits were divided into 5 groups by random number table method: blank group, model group, glucosamine hydrochloride (GH) group, PIPM group and PIPM combined with GH group. The rabbits were then modeled. Results: After 9-weeks cultured in groups, 5 ml blood was collected from the heart, and cytokines were detected. The result suggested that iNOS, NO and TNF-α were the pathogenic inflammatory factor of KOA, and aggravated cartilage damage and degeneration. Besides, this study indicated that PIPM combined with GH treatment significantly reduced the activity of inflammatory cytokines in serum and joint fluid of KOA models in rabbits. In addition, PIPM combined with GH therapy exhibited the best therapeutic effect among these treatments, which was working on KOA better than PIPM treatment alone or GH treatment alone.
Highlights
Knee osteoarthritis (KOA), known as degenerative knee arthritis or deformable knee arthritis, is a chronic joint disease characterized by degeneration of articular cartilage and secondary hyperosteogeny, mainly manifestations are knee joint pain, swelling, stiffness, weakness and dysfunction.[1]
As shown in Figure: 1, the activity of Inducible nitric oxide synthase (iNOS), Nitric oxide (NO) and TNF-α in the model group was significantly higher than that in the blank group (P
patellar inward pushing method (PIPM) combined with glucosamine hydrochloride (GH) treatment has the most significant inhibition ability to iNOS when compared with other groups (P < 0.01)
Summary
Knee osteoarthritis (KOA), known as degenerative knee arthritis or deformable knee arthritis, is a chronic joint disease characterized by degeneration of articular cartilage and secondary hyperosteogeny, mainly manifestations are knee joint pain, swelling, stiffness, weakness and dysfunction.[1] KOA is a complete, multilevel, and varying degree of aseptic, chronic, and progressive disease of the bone, synovial membrane, joint capsule and other joints.[2] KOA is very common in clinic, especially in the middle and old age Biomedica – Vol 36, Issue 4, 2020. Patellar Inward Pushing Method Relieves Knee Osteoarthritis Via Regulating Cytokines population, which seriously affects the quality of life of patients.[3,4] According to China's epidemiological survey, the prevalence rate of KOA in China among people aged 60 – 75 years was 50%, and that of people aged over 75 years was as high as 80%.55. Knee osteoarthritis (KOA) is a chronic degenerative disease characterized by pain, morning stiffness and swelling in the knee joints. This study aimed to explore the curative effects of patellar inward pushing method (PIPM) on KOA
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