Abstract
We have proposed free-standing centimeter-sized ultra-thin films (nanosheets) for biomedical applications. Such nanosheets exhibit unique properties such as transparency, flexibility, and good adhesiveness. However, they are only easily adhered to broad and flat surfaces due to their dimensions. To this end, we recently proposed an innovative nanomaterial: the nanosheets fragmented into submillimeter-size pieces. Intriguingly, such fragmented nanosheets could be adhered to uneven and irregular surfaces in addition to flat surfaces in a spread-out “patchwork” manner. We herein review the fabrication procedure and characterization of fragmented nanosheets composed of biodegradable polyesters and thermostable bio-friendly polymers, and their biomedical applications in burn therapy and antithrombotic coating using a “patchwork coating”.
Highlights
In the field of nanotechnology, free-standing ultra-thin films composed of organic materials, inorganic materials or their combination have been proposed as innovative two-dimensional nanomaterials [1,2,3]
We have recently proposed the use of bio-friendly nanosheets for biomedical applications [10,11,12,13,14,15,16,17]
We describe the fundamental features of centimeter-sized bio-friendly nanosheets composed of biodegradable polyesters (PLLA), biocompatible polyimides, and segmented polyurethanes containing PC groups developed in our groups
Summary
In the field of nanotechnology, free-standing ultra-thin films composed of organic materials, inorganic materials or their combination have been proposed as innovative two-dimensional nanomaterials [1,2,3]. A large number of fabrication procedures have been proposed; e.g., layer-by-layer deposition of the polyelectrolytes themselves or polyelectrolytes and inorganic materials with opposite net charges [4,5], Langmuir-Blodgett films of amphiphilic polymers [6], and a sol-gel process to synthesize interpenetrating polymer networks [7], polymerized lipid films [8,9], and so on Using their structural features, large-surface-area nanosheets have been applied in a wide variety of fields, e.g., electrochemical studies and separation technologies such as sensors, energy storage, and selective adsorption. We describe the fundamental features of centimeter-sized bio-friendly nanosheets composed of biodegradable polyesters (PLLA), biocompatible polyimides, and segmented polyurethanes containing PC groups developed in our groups (named as PIPC and SPUPC, respectively). The fragmented PIPC and SPUPC nanosheets would be suitable for the latter application to sterilize medical devices exposed continuously to blood such as catheters and artificial organs, etc
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