Abstract
Abstract Invented by Bert Sakmann and Erwin Neher during the 1970s, the patch-clamp recording technique aids scientists in examining the functions of individual protein molecules that form ion channels in cell membranes. The importance of this outstanding contribution, which has revolutionized neurophysiology and greatly augmented understanding of cell membranes, is underscored by the fact that Sakmann and Neher received the Nobel Prize in 1991. The fundamental finding arising from patch-clamp experiments is that currents through cell membranes pass through protein channels. This chapter provides a brief introduction to the patch-clamp technique and presents the fundamental equations that govern currents through individual ion channels. The electrophysiology of three types of ion channels is described: nongated chloride channels, voltage-gated sodium and potassium channels, and ligand-gated acetylcholine channels.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
