Abstract
Debate surrounds the validity of patch testing for allergic contact dermatitis in patients taking immunosuppressants and the extent to which these medications suppress patch test reactions. Previous studies have demonstrated that corticosteroids can suppress immune reactions measured in patch testing. Because immunomodulators are increasingly used, their impact on patch testing also requires evaluation. This study aimed to report patch test results in patients taking specific immunosuppressants and to review relevant literature. A retrospective review of patients patch tested with the standard series at Mayo Clinic in Rochester, Minnesota, between January 1, 2008, and December 31, 2011, was conducted. Positive patch test results occur during methotrexate therapy. How reactions would differ with no immunosuppression is unclear.
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