Abstract
Pasteurella multocida can cause a variety of diseases in various species of mammals and birds throughout the world but nothing is known about its importance for wild great apes. In this study we isolated P. multocida from wild living, habituated chimpanzees from Taï National Park, Côte d'Ivoire. Isolates originated from two chimpanzees that died during a respiratory disease outbreak in 2004 as well as from one individual that developed chronic air-sacculitis following this outbreak. Four isolates were subjected to a full phenotypic and molecular characterisation. Two different clones were identified using pulsed field gel electrophoresis. Multi Locus Sequence Typing (MLST) enabled the identification of previous unknown alleles and two new sequence types, ST68 and ST69, were assigned. Phylogenetic analysis of the superoxide dismutase (sodA) gene and concatenated sequences from seven MLST-housekeeping genes showed close clustering within known P. multocida isolated from various hosts and geographic locations. Due to the clinical relevance of the strains described here, these results make an important contribution to our knowledge of pathogens involved in lethal disease outbreaks among endangered great apes.
Highlights
Pasteurella multocida is a gram negative coccobacillus which colonizes the nasopharynx of many wild and domestic animals
Isolation of P. multocida was achieved for three different individuals: three isolates originated from two females that died in the respiratory outbreak in 2004 (IMT18907, IMT18908, both from ‘‘Virunga’’, and IMT18909, from ‘‘Ophelia’’)
The sequence types (STs) found in the chimpanzees group together with strains of the latter group. This is the first description of P. multocida isolated from wild great apes
Summary
Pasteurella multocida is a gram negative coccobacillus which colonizes the nasopharynx of many wild and domestic animals. It has a wide disease and host spectrum, ranging from clinical conditions where it is considered a primary pathogen, such as hemorrhagic septicaemia in cattle and fowl cholera in birds, through to conditions where it can behave as a secondary invader, for example in cases with pneumonic lesions [1,2]. P. multocida may cause upper respiratory tract infections, including sinusitis, epiglottitis and pharyngitis [3,6]. P. multocida is an infrequent cause of systemic infections such as meningitis and septicaemia, especially in the very young, the elderly and the immunocomprised [6,10]
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