Abstract
Some previous streaming potential and EMF measurements on human stratum corneum in vitro (J. Control. Release 32 (1994) 249) are explained in terms of a simple physical model based on the intercellular pathway for passive transport of small inorganic ions. These are assumed to diffuse across the hydrophilic region of the lipid lamellae. The polar region is assumed to have a finite thickness and to be partly penetrable by ions from solution. The hypothesis that the lipid ionized groups give rise to a point charge distribution together with a permanent dipole distribution helps to explain the observed, apparent change in skin selectivity with concentration.
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