Abstract
Previous studies have shown that immediate urticarial reactions of the Prausnitz-Kustner type may be produced in human skin after passive sensitization with sera from rabbits sensitized with ovalbumin and with sera from guinea pigs sensitized to pollens of grass or ragweed1, 2. The present study concerns the activity in passively sensitizing human skin of sera from guinea pigs sensitized with crystalline ovalbumin, and the relationship of that activity to the capacity of the same anti-sera to produce passive anaphylactic sensitivity in the guinea pig.Samples of sera obtained from guinea pigs sensitized by various methods at the Allergen Research Division of the Department of Agriculture were tested in the passive sensitization of human skin at Roosevelt Hospital. Other portions of the same antisera were tested in the passive anaphylaxis of guinea pigs at the Allergen Research Division.Methods. To determine activity in passive anaphylaxis, serial dilutions of each serum (differing by a factor of 1.5) were ...
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Schedule a callMore From: Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.)
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