Abstract
Passive induction of experimental autoimmune encephalomyelitis by activated or tolerogenic dendritic cells
Highlights
Both MS and EAE are characterized by the infiltration of inflammatory cells, including T cells, B cells, macrophages and DCs and demyelination of axonal tracks in the central nervous system.[1]
TolDCs have emerged as clinical targets for the treatment of autoimmunity. This protocol describes a method for passive induction of EAE by adoptive transfer of DCs primed with myelin antigen into naïve mice
We have shown the ability of inducing EAE between activated DCs and TolDCs in associated publication “A unique tolerizing dendritic cell phenotype induced by the synthetic triterpenoid CDDO-DFPA \(RTA-408) is protective against EAE” in _Scientific report._
Summary
Both MS and EAE are characterized by the infiltration of inflammatory cells, including T cells, B cells, macrophages and DCs and demyelination of axonal tracks in the central nervous system.[1]. Induction of EAE results infiltration of T cells and demyelination of axon in central nervous system, further leading the clinical symptoms of MS. This protocol describes a method for passive induction of EAE by adoptive transfer of DCs primed with myelin antigen into naïve mice.
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