Abstract
THE malignant lymphoma induced by herpesvirus saimiri (HVS) in non-human primates1 provides a model system for the study of the prevention of neoplasia in man induced by suspected oncogenic herpesviruses2. We have reported that cotton topped (CT) marmoset monkeys (Saguinus oedipus) actively immunised with a killed HVS vaccine were resistant to the inoculation of the oncogenic HVS while the non-vaccinated control monkeys died of malignant lymphoma3. In certain virus infections (for example measles infectious hepatitis German measles) passive immunisation by administration of specific serum antibodies during the incubation period may result in prevention or modification of the clinical disease. This paper describes the prevention of herpesvirus induced malignant lymphoma in monkeys by passive immunisation.
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