Abstract
Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis. However, accumulation issues have prevented their clinical translation, while their use in catalysis has shown serious efficiency and stability hurdles. Here we introduce a simple and robust synthetic protocol for passion fruit-like nano-architectures composed by a silica shell embedding polymeric arrays of ultrasmall noble metal nanoparticles. These nano-architectures show interesting features for both oncology and catalysis. They avoid the issue of persistence in organism thanks to their fast biodegradation in renal clearable building blocks. Furthermore, their calcination results in yolk-shell structures composed by naked metal or alloy nanospheres shielded from aggregation by a silica shell.
Highlights
Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis
We have recently introduced a 100 nm biodegradable passion fruit-like nano-architecture in which 3 nm gold NPs are strictly packed in polymer arrays surrounded by a silica shell[20]
NPs were assembled in spherical arrays by a controlled aggregation achieved by ionic interaction with positive poly(L-lysine) (PL) 15–30 kDa
Summary
Noble metal nanostructures have demonstrated a number of intriguing features for both medicine and catalysis. We introduce a simple and robust synthetic protocol for passion fruit-like nano-architectures composed by a silica shell embedding polymeric arrays of ultrasmall noble metal nanoparticles These nano-architectures show interesting features for both oncology and catalysis. : i) translation of nanotechnologies in medicine needs to combine the feasibility of body clearance typical of ultrasmall NPs with the physical behaviour of bigger NPs10, and ii) metal NPs based catalysis can be effective only if reactive naked metal surfaces and colloidal stability are provided jointly[19] In this regard, we have recently introduced a 100 nm biodegradable passion fruit-like nano-architecture in which 3 nm gold NPs are strictly packed in polymer arrays surrounded by a silica shell[20]. Despite other nanomaterials may share similar structure with passion fruit-like nano-architectures, the synthetic protocol and the final behaviours are not overlapping[22]
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