Abstract
Thirty dogs, whose thoracic ducts were catheterized, were divided into three groups. Each group was bled and simultaneously infused with either an erythrocyte-serum or an erythrocyte-plasma suspension. Those dogs bled and infused with the former suspension lost 35% of the initial plasma fibrinogen concentration. Recovery occurred in 4 hr but was shortened by 50% if the thoracic duct catheter was inserted into a venous catheter between samplings. Fibrinogen delivered via the lymphatics accounted for 50% of recovered blood fibrinogen. The rate of delivery via lymphatics was characteristically biphasic: an immediate, sharp increase postinfusion and hemorrhage followed by a delayed, less pronounced yet sustained increase. The rate of lymphatic delivery of fibrinogen in dogs receiving the erythrocyte-plasma suspension followed the diminishing rate of lymph flow. The albumin, globulin, and total protein concentrations in blood and lymph of all dogs remained fairly constant, attesting to selectivity in response to fibrinogen depletion in blood.
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