Abstract
Pasireotide after Surgery for Persistent Cushing’s Disease
Highlights
Cushing’s disease (CD) is characterized by multiple complications, due to the condition itself, and as a result of curative treatment
Cuvinte cheie: chirurgie, boala Cushing, diabet zaharat, pasireotide. It is a rare disease, the increased morbidity associated with CD requires multiple therapeutic approaches, especially in case of persistent hypercortisolism.The first-line treatment is represented by transsphenoidal surgery, but medical therapy is a sustainable option in case of recurrent or persistent CD, when surgery is contraindicated or until radiation therapy has taken full effect[1]
Pasireotide is a new-generation multi-receptor-targeted somatostatin receptor ligand used in the treatment of CD, but its effect on glucose metabolism should be taken into consideration when choosing the best treatment option for each patient[2]
Summary
It is a rare disease, the increased morbidity associated with CD requires multiple therapeutic approaches, especially in case of persistent hypercortisolism.The first-line treatment is represented by transsphenoidal surgery, but medical therapy is a sustainable option in case of recurrent or persistent CD, when surgery is contraindicated or until radiation therapy has taken full effect[1]. Pasireotide is a new-generation multi-receptor-targeted somatostatin receptor ligand used in the treatment of CD, but its effect on glucose metabolism should be taken into consideration when choosing the best treatment option for each patient[2]
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