Parylene based flexible glucose sensor using glucose-responsive fluorescent hydrogel

Abstract

We propose a flexible glucose sensor combined with a parylene based electrode and a glucose-responsive fluorescent hydrogel for continuous monitoring of glucose concentration. By depositing parylene-C on a cupper (Cu) thin sheet and creating electrical circuits including a LED and a photo diode, we developed the flexible glucose sensor. The flexible glucose sensor could reduce damage to tissues and organs of patients because the flexibility allows its deformation following movements of the patients. Using the flexible glucose sensor, we succeeded in wireless measurement of glucose concentration in vivo by implantation of the sensor into a rat.