Abstract
Abstract Objectives Human parvovirus B19, the cause of fifth disease in children and transient arthropathy in adults, could induce autoimmunity and the production of autoantibodies. The aim of this study is to explore the relationship between B19 infection and autoantibodies upregulation in women and children. Methods Of 512 women and children in our hospital between 2016 and 2018, all cases simultaneously test anti-B19 IgM and autoantibodies like anti-nuclear antibody, anti-Sm and anti-double stranded DNA antibody were included in this study. Results Parvovirus B19 infection could significantly upregulate anti-nuclear antibody and anti-Sm, but not anti-double stranded DNA, the titer of autoantibodies is associated with the content of anti-B19 IgM, and the infection in children is accompanied with more obvious autoantibodies upregulation. Conclusions Our data shows that parvovirus B19 infection is related to autoantibodies production in both women and children, and the status of infection may associate with the titer of autoantibodies in parvovirus B19 infected patients.
Highlights
Human parvovirus B19, a single-stranded DNA virus, preferentially targets the red blood cell precursors in the bone marrow
Parvovirus B19 infection could significantly upregulate anti-nuclear antibody and anti-Sm, but not anti-double stranded DNA, the titer of autoantibodies is associated with the content of anti-B19 IgM, and the infection in children is accompanied with more obvious autoantibodies upregulation
Our data shows that parvovirus B19 infection is related to autoantibodies production in both women and children, and the status of infection may associate with the titer of autoantibodies in parvovirus B19 infected patients
Summary
Human parvovirus B19, a single-stranded DNA virus, preferentially targets the red blood cell precursors in the bone marrow. The virus is widespread, especially in children, causing erythema infectiosum, a childhood exanthem characterized by slapped cheek rash. Infection is occasionally associated with symmetric polyarthropathy that mimic rheumatoid arthritis. Parvovirus B19 infection has been demonstrated to induce autoimmunity and mimic the manifestation of autoimmune disease, like systemic lupus erythematosus (SLE) [2,3,4,5]. It has been reported that parvovirus B19 may be associated with childhood idiopathic thrombocytopenic purpura (ITP) [6]. Whether parvovirus B19 infection causes autoimmune diseases or just clinical mimicry deserves further investigation
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.