Parvalbumin-positive small myelinated fiber bundles in anterior marginal areas in the human cervical cord

Abstract

During pathological examinations of amyotrophic lateral sclerosis (ALS) patients, we noticed that bundles of dense small myelinated fibers were relatively well preserved in the anterior marginal areas of the cervical cords in a few ALS patients with diffuse myelin pallor. Moreover, these fibers were strongly immunostained by anti-parvalbumin antiserum. These parvalbumin-positive fiber bundles were also seen in other ALS and non-ALS patients, and they were continuously traced up to the spinothalamic tract areas of the medulla oblongata. Therefore, it is suggested that these fiber bundles belong mainly to the ventral spinothalamic tract. We considered that these fiber bundles became conspicuous in shape since other areas in the anterolateral funiculus showed myelin pallor in such ALS patients.