Abstract
Partners in death: a role for p73 and NF-kB in promoting apoptosis
Highlights
The p53 and NF-kB families of transcription factors play key roles in the regulation of cell death and cell viability
Martin et al show that DNA damageinduced apoptosis in immortalised and transformed mouse embryo fibroblasts depends on the presence of the NF-kB sub-unit, p65
Previous studies had shown a similar dependence on p65 for the induction of p53induced death in several systems [7]. In this case the cells used by Martin et al expressed an inactive mutant form of p53 - so these studies reveal a further role for p65 in the activation of p53-independent apoptosis
Summary
The p53 and NF-kB families of transcription factors play key roles in the regulation of cell death and cell viability. Best understood are the functions of p53 - and its related family member p73 - in driving cell death, and the ability of NF-kB to promote cell survival [1,2,3].
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