Partitioning innate and acquired immunity in mice after infection with Nematospiroides dubius

Abstract

Sera from donor mice (selected as refractory ( R), random ( Rd) and liable ( L) to Nematospiroides dubius) after a single infection with 100 N. dubius larvae of 3 weeks duration, each transferred partial protection to the same degree in recipient C3H and Quackenbush mice. These results supported the conclusion that differences in the numbers of faecal N. dubius eggs voided by the R, Rd and L mice after 11 generations of selective breeding resulted from differences in their innate immunity.