Abstract
Abstract The partition coefficients (log P) in n-butanol/water and n-octanol/water together with the HPLC capacity factors (k') in 2% and 4% acetonitrile (ACN) and aqueous buffered mobile phase were determined for 21 Gd(III) chelates of linear and macrocyclic polyamino carboxylates. A C18 reversed-phase (Nucleosil) column was used for determination of k'. The log P values were calculated (clog P) for the fully protonated form of the ligands. A reasonably good correlation (r = 0.76) between the measured log P values for the chelates in n-butanol/water and the calculated log P values for the ligands was observed. In general, the log P value in n-butanol/water for a chelate was 1.3 log unit different than that in n-octanol/water. The k' values in 2% and 4% acetonitrile/aqueous buffer were also correlated with measured log P values.
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