Particulate matter-induced skin inflammation is suppressed by polyphenol-enriched dietary supplement via inhibition of the AhR/ARNT signaling pathway

Abstract

Environmental factors that cause skin diseases cause an inflammatory response and cause various diseases. In this study, the ability of polyphenol-enriched dietary supplement (Zeropollution, ZP), a mixture of four types of natural extracts, to inhibit skin inflammation caused by particulate matter (PM) and ultraviolet B (UVB), was evaluated using an experimental mouse model (HR-1 or SKH-1 mice) and human keratinocytes (HaCaT cells). Treatment with ZP significantly inhibited the levels of pro-inflammatory markers, such as cyclooxygenase-2 (COX-2) and cytochrome P450 family 1 subfamily A1 (CYP1A1). In addition, the pro-inflammatory cytokines, tumor necrosis factor-α (TNF-α) and interleukin-1α (IL-1α), were decreased by ZP pretreatment before exposure to PM10 or UVB. In particular, ZP significantly inhibited the expression of the aryl hydrocarbon receptor (AhR) and aryl hydrocarbon receptor nuclear translocator (ARNT), which initiate inflammatory responses by sensing PM10 and UVB. Therefore, these results suggest that ZP has the potential to be used as a material for the development of a naturally derived functional compound that can prevent skin aging triggered by PM10 and UVB.