Particularités de l’hémostase du nouveau-né

Abstract

Paediatric haemostasis is described as an evolving system with qualitative and quantitative changes and maturation throughout the foetal, neonatal and childhood period. Nevertheless, the haemostatic system remains balanced in full-term infant, without bleeding nor thrombosis but this balance is fragile. The interpretation of the haemostasis tests must take into account the reference values specific to each age group and each analytical system, as well as the postnatal and gestational age, but also the preanalytical difficulties frequently encountered during blood collection in the newborn. The majority of haemorrhagic and thrombotic disease in the newborn have an acquired origin. Only severe constitutional abnormalities homozygous or heterozygous composite are revealed by neonatal complications. A good knowledge of haemostatic system peculiarities in the neonatal period is also mandatory for the monitoring of anticoagulant treatment.