Particularités cliniques, radiologiques et biologiques des spondylarthropathies libanaises selon la présence ou l'absence du HLA-B27

Abstract

Clinical, radiological, and laboratory findings in Lebanese spondylarthropathy patients according to HLA-B27 status. — Objective. To evaluate clinical, radiological, and laboratory features in Lebanese spondylarthropathy patients according to HLA-B27 status. Methods. We retrospectively compared demographic, clinical, radiological, and severity data in 40 HLA-B27-positive and 58 HLA-B27-negative patients. All 98 patients met Amor's or European Spondylarthropathy Study Group criteria for spondylarthropathy, and 51.7% met New York modified criteria for ankylosing spondylitis. Results. Onset before 16 years of age, hip involvement, and an elevated mean erythrocyte sedimentation rate were significantly associated with the presence of the HLA-B27 (32.5 vs 13.8%, p = 0.02; 45 vs 7.5%, p = 0.001; and 47.7 vs 25.4, p = 0.02; respectively). The two groups were comparable for age, sex ratio, prevalence and distribution of spondylarthropathy types, family history, sacroiliitis, bamboo spine, syndesmophytes, peripheral joint involvement, enthesopathies, extraarticular involvement, response to nonsteroidal antiinflammatory drugs, and need for other medications. Conclusion. In Lebanon, spondylarthropathy patients positive for HLA-B27 experience disease onset at an earlier age, are more likely to develop hip involvement, and have laboratory evidence of more severe inflammation than their HLA-B27-negative counterparts. None of the other clinical and radiological parameters are modified by HLA-B27 status.