Abstract
Clostridium difficile infection (CDI) is a new pathology, but increasingly common in the elderly patient, with multiple comorbidities that often alter his quality of life and aggravate his vital prognosis. Material and method: The study is a prospective, observational, controlled active study, performed on 706 patients admitted to the Hospital St. Parascheva Galați Infectious Diseases Clinical Hospital ” between 1.01.2017 ÷ 31.12.2018 with the diagnosis of CDI, of which 69 patients were associated with psychiatric disorders (PD). Results: The demographic, clinical and paraclinical characters that differentiated the group with CDI and PD from the group with CDI and various comorbidities, statistically significant, were:female sex, predominant in the group with PD, older age in the group with PD, Charlson score with values higher in the PD group, Atlas score with higher values in the PD group, the number of deaths that occurred in the first 30 days after the CDI episode, as well as the number of deaths that occurred in the first 6 months after the CDI, higher in the group with CDI and PD compared to the group with CDI and various comorbidities.
Highlights
Clostridium difficile Infection (CDI) is an important public health problem in Romania
The origin of the cases in the group with patients with CDI and various comorbidities was: 553 (78.32%) patients with infection associated with healthcare, and 153 (21.67%) patients with infection with indefinite and community source, and in the group of patients with CDI and psychiatric disorders (PD) was: 61 (88.40%) patients with healthcare associated infection, and 8 (11.59%) patients with indefinite and community source infection
The percentage of nosocomial infections was higher in the PD group with 10.08% without being statistically significant
Summary
Clostridium difficile Infection (CDI) is an important public health problem in Romania. Risk factors for mortality from CDI are considered: age, comorbidities, hypoalbuminemia, leukocytosis, acute renal failure and ribotype 027 infection (Abou Chakra et al, 2014). The risk of CDI among LTCF residents is seven times higher compared to individuals in the community (Karanika et al, 2017). This increased risk is due to multiple risk factors for CDI in this patient population, including age, frequent antimicrobial exposure, multiple comorbidities, and recurrent hospitalizations (Karanika et al, 2017; Ziakas et al, 2015; Ziakas et al, 2016)
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