Abstract
Supercritical fluid extraction and expansion (SFEE) patented technology combines the advantages of both supercritical fluid extraction (SFE) and rapid expansion of supercritical solution (RESS) with on-line coupling, which makes the nanoparticle formation feasible directly from matrix such as Chinese herbal medicine. Supercritical fluid extraction is a green separation technology, which has been developed for decades and widely applied in traditional Chinese medicines or natural active components. In this paper, a SFEE patented instrument was firstly built up and controlled by LABVIEW work stations. Stearic acid was used to verify the SFEE process at optimized condition; via adjusting the preexpansion pressure and temperature one can get different sizes of particles. Furthermore, stearic acid was purified during the SFEE process with HPLC-ELSD detecting device; purity of stearic acid increased by 19%, and the device can purify stearic acid.
Highlights
The size of organic and inorganic materials is a key factor that can determine its final use
Liquid carbon dioxide with purity of 99.9% used for supercritical fluid extraction and expansion (SFEE) process was purchased from Praxair Gas Co. (Beijing, China)
Preextraction temperature and expansion temperature are heated controlled by incubator, which is formed from two chambers, resulting in temperature, respectively, controlled, without interference
Summary
The size of organic and inorganic materials is a key factor that can determine its final use. The well-known conventional processes for particle size redistribution of solid materials are crushing [1] or grinding [2], carried out at cryogenic temperatures for some compounds [3], air micronization, sublimation [4], or recrystallization from solution [5]. Supercritical fluid technology has been widely used for various applications such as extraction, reaction, chromatography and material processing [7, 8]. Micronization of Stearic acid using supercritical fluid technology involves much simpler steps that can eliminate many disadvantages of the traditional processes [13, 14]. Examinations of the solidstate properties such as the particle size and its distribution, as well as the purity change of stearic acid after processing by SFEE, that is, stearic acid solubility in the CO2 SCF, are demonstrated
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