Abstract
Improved performance with the latex agglutination immunoassay, PACIA, is possible when the F(ab′) 2 fragments of antibody are chemically coupled at their hinge region to a protein-coated latex using a new coupling reagent, N ϵ -chloroacetyl lysine N-carboxyanhydride. This reagent, whether by orientating the complete antibody molecule or its F(ab′) 2 fragment or by preventing antibody denaturation, increased the sensitivity of the PACIA method. The use of F(ab′) 2 fragments eliminated most serum interference with the test.
Published Version
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