Abstract
Imipenem/Cilastatin (IPM/CS) is currently used as an embolic agent in transarterial embolization for chronic musculoskeletal pain due to its efficacy of short-term blood flow occlusion. However, due to its off-label use, the development of new materials to substitute IPM/CS is needed. Therefore, investigating the behavior of IPM/CS particles becomes crucial. In this paper, we observed the changes in particle size of IPM/CS when dissolved in phosphate-buffered saline, normal saline, iodinated contrast agent and water. The results indicated that the particle size of IPM/CS ranged from 16 to 57 µm and has fastest hydrolysis rate in iodinated contrast agent. And we analyzed the possible structure of hydrolyzed product of IPM/CS in water at room temperature and 37 ℃ using 1HNMR, HPLC. The results suggested Cilastatin is stable at both temperatures, while Imipenem hydrolyzed to produce slightly different products at different temperatures.
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