Abstract
In germinal loci of a brain, as well as in tissues of peripheral organs there are morphofunctional zones in which a proliferation and differentiation of cambial cells occur. The hypothalamus with hypophysiotropic region represents the central zone. One of the key proteins of morphofunctional zones is the Src-kinase, participating in transfer of a nervous signal, if it is in its active form. The hypothalamus initially has a high expression of an inactive Src-kinase which is connected with the development of a brain from an ectoderm. With aging due to the influence of the estrogens, which activate the Src-kinase, the resources of an inactive Src in a hypothalamus are exhausted, which leads to violation of release of many hormones including AKTH. Local accumulation in hippocampus of the glucocorticoids, which have inhibitory effect on neurons can lead to neurodegenerative diseases at low congenital level of the Src-kinase in the hypothalamus and also the stresses strengthening emission of glucocorticoids.
Highlights
In germinal loci of a brain, as well as in tissues of peripheral organs there are morphofunctional zones in which a proliferation and differentiation of cambial cells occur
Tissues of peripheral organs are constructed as the morphofunctional zones, consisting of two subunits with 12 cambial cells in each, at which division 12 pairs of mother and daughter cells are formed [1]
The starting moment in carrying out a nervous impulse at adrenocorticotropic hormone (AKTH) synthesis is the decrease in a share of inactive Srckinase under the influence of light in retina photoreceptors and melanopsin cells. It leads to the increase in a share of the active Src-kinase in them, strengthening an exocytosis and decrease in neurotransmitters number, because the stretching of chromosomes loci will be displaced to a centromere, which will cause recession of their synthesis
Summary
In germinal loci of a brain, as well as in tissues of peripheral organs there are morphofunctional zones in which a proliferation and differentiation of cambial cells occur. If the portion of the active Src-kinase begins to increase, stretching occurs closer to a centromere, and fibroblast-like cells are formed [6]. The function of the neurotransmitters developed by cells of a brain is directed to strengthening of inactive Src-kinase portion in neurons.
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