Abstract
1. 1. Some extraneous proteins retarded the auto-activation of the insect dihydrofolate reductase. Their effect seems to be connected with protection of the enzyme SH groups. 2. 2. All tested thiol compounds prevented and reversed the auto-activation of dihydrofolate reductase. 3. 3. The enzyme was found to be activated by several SH reagents and their effect was also prevented and reversed by thiol compounds. 4. 4. The supposition was made that during the process of auto-activation of the insect dihydrofolate reductase, oxidation of its SH groups occurs, which results in a catalytically more favourable enzyme conformation.
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