Abstract
This study evaluated the epithelial expression of hMLH1, MDM2, and p63 in lower lip actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Study Design: Forty cases of AC and 40 cases of SCC underwent immunoperoxidase method analysis. A thousand cells of each case were counted for immunohistochemical analysis. The data were analyzed quantitatively, and expression was compared by Mann-Whitney, Student t-test, or one-way ANOVA (p ≤ 0.05). Results: The hMLH1 expression was higher in cases of AC without dysplasia or with mild dysplasia (721.23 ± 88.116), whereas fewer positive cells were observed in lower lip SSCs (255.03 ± 199.47) when compared to the AC group (p < 0.001).
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