Abstract
A critical issue for current liposomal carriers in clinical applications is their leakage of theencapsulated drugs that are cytotoxic to non-target tissues. We have developedpartially polymerized liposomes composed of polydiacetylene lipids and saturatedlipids. Cross-linking of the diacetylene lipids prevents the drug leakage even at40 °C for days. These inactivated drug carriers are non-cytotoxic. Significantly, more than70% of the encapsulated drug can be instantaneously released by a laser that matches theplasmon resonance of the tethered gold nanoparticles on the liposomes, and the therapeuticeffect was observed in cancer cells. The remote activation feature of this novel drugdelivery system allows for precise temporal and spatial control of drug release.
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