Abstract
Motor-evoked potentials elicited from transcranial magnetic stimulation were recorded from both cranial tibial muscles of 10 Lewis rats. One sciatic nerve was then transected and surgically reanastomosed and allowed to regenerate for 6 weeks. Walking function was tested weekly using a footprint test giving a functional sciatic nerve index. At the end of the study motor-evoked potentials were again performed, as were nerve conduction velocities and supramaximal stimulation of operated and unoperated sciatic nerves. The nerve was evaluated for myelinated axon numbers. Functional sciatic index, numbers of myelinated axons, nerve conduction velocities, and supramaximal stimulation demonstrated the regenerated nerve to be functional, but to a lesser extent then the unoperated nerve. In all cases the amplitude of the compound muscle action potential evoked from transcranial magnetic stimulation of the motor cortex was greater in the operated motor pathway. This finding demonstrates hyperexcitability of the motor pathway to magnetic stimulation during peripheral nerve regeneration.
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