Abstract
Apparent molar volume (Vphi), partial molar volume (V), solute-solute interaction parameter (Sv), partial molar expansivity (E(0)2) and isobaric thermal expansion coefficient (alpha2) of mefenamic acid in six different organic solvents namely, methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol, have been calculated from the measured solution densities over a temperature range of T=293.15 and T=313.15±0.1K. The solution densities were measured by an automated vibrating tube densitymeter (Anton Paar DMA-48). The molality range investigated was between 6×10-3 and 3.25 ×10-2 mol kg -1. The effect of temperature on apparent molar volume and partial molar volume was also determined. Decrease in solute-solvent interactions with an increase in temperature has been noted. Partial molar volume of mefenamic acid changes with the change in solvent polarity.
Highlights
In biophysical chemistry drug-macromolecular interaction is an important phenomenon involving complex molecular mechanism
Macromolecule interactions, the results of the determinations of apparent molar volumes (VΦ), partial molar volume (V– ), solute-solvent interaction parameter (S ), partial molar v expansivity (E02) and isobaric thermal expansion coefficient (α2) of mefenamic acid in six different organic solvents i.e. methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol between T=293.15 and T=313.15±0.1 K are reported in the present study
The apparent molar volume data for mefenamic acid dissolved in methanol, ethanol, 1-propanol, 2-propanol, 1-butanol and 2-butanol (Figures 1-6) increases with concentration at a particular temperature
Summary
In biophysical chemistry drug-macromolecular interaction is an important phenomenon involving complex molecular mechanism. Soc. macromolecule interactions, the results of the determinations of apparent molar volumes (VΦ), partial molar volume (V– ), solute-solvent interaction parameter (S ), partial molar v expansivity (E02) and isobaric thermal expansion coefficient (α2) of mefenamic acid in six different organic solvents i.e. methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, and 2-butanol between T=293.15 and T=313.15±0.1 K are reported in the present study.
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