Abstract
Twin pregnancy of a hydatidiform mole with a coexistent live fetus is very rare, and complete molar pregnancy is involved in most cases. A partial molar pregnancy almost always ends in miscarriage due to a triploid fetus. Here, we report a case of a 32-year-old Chinese woman with ultrasound diagnosis of a partial molar pregnancy. Amniocentesis suggested mosaicism, but the fetus was morphologically normal. The woman chose to continue the pregnancy after fully understanding the risk. The infant was delivered prematurely, and the presence of a large single placenta with molar changes. The baby’s peripheral blood chromosomes were diploid, and the pregnant woman had no serious complications. The diagnosis, management, and monitoring of this condition will remain challenging because of its rarity. Partial hydatidiform mole combined with pregnancy can result in delivering of a normal fetus and live birth under proper management.
Highlights
Twin pregnancy with hydatidiform mole and a coexistent live fetus is a very rare condition occurring in 0.005% to 0.001% of all pregnancies [1]
We report a case of a 32-year-old Chinese woman with a partial molar pregnancy and live birth of a diploid infant
complete hydatidiform mole (CHM) consists of a diploid set of 46 chromosomes, and all genetic material is of paternal origin, with no fetal structure; it is noteworthy that the risk for trophoblastic sequelae (15%–20%) is higher than that of pregnancy with Partial hydatidiform moles (PHM) (
Summary
Twin pregnancy with hydatidiform mole and a coexistent live fetus is a very rare condition occurring in 0.005% to 0.001% of all pregnancies [1]. Ultrasonography (US) revealed a fetus with normal anatomy and an appropriate amniotic fluid volume. A provisional diagnosis of hydatidiform mole coexisting with a live fetus was proposed. The patient underwent amniocentesis, and the amniotic fluid karyotype revealed was: 46, XN[51]/92, XXNN[34]. False mosaic phenomenon in amniocentesis had not been ruled out so we suggested performing an umbilical cord blood puncture or amniotic fluid cell fluorescence in situ hybridization (FISH) review to determine whether it was true mosaicism or pseudomosaicism, but the patient refused further examination because of economic reasons. On 24th June 2018 (29 weeks and 3 days of gestation), the patient experienced increased vaginal bleeding and abdominal pain and was admitted to hospital. Uterine contractions increased on the third day of hospitalization The patient and her spouse were counselled on the risks and implications of the diagnosis. Informed consent: Informed consent was obtained from all individuals included in this study
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