Abstract
MOLECULAR hybridizations between DNA from normal mice and RNAs from immunocompetent cells exposed to antigen showed that (a) new species of RNA appeared in cells stimulated by antigen1, and (b) different species of RNA appeared in immunocompetent cells exposed to different antigens2. Similar results were obtained by Church et al.3. In the work reported here, RNAs from immunocompetent cells exposed to sheep red blood cells (RBC) were hybridized with DNA immobilized in a nitrocellulose column. The RNAs which failed to form hybrids and passed through the column were analysed.
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