Abstract
The cardiac myofilament is a protein assembly that enable the heart to undergo alternating periods of contraction and relaxation, the driving force regulated by Ca2+. Troponin, a three-member protein assembly within the myofilament, acts as a Ca-sensitive switch. In this work, we used single molecule FRET technique to monitor whether the Troponin complex functions as a Ca2+ -sensitive regulatory switch . The results show a population of unactivated troponin under saturating Ca2+ conditions. We propose that the population of unactivated troponin comprises a form of cardiac reserve that is regulated by signaling pathways that target the myofilament.
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