Abstract
AbstractA trial was made to enhance the release of Rifampicin from topical preparations by incorporating it in the form of solid dispersion with water soluble carriers. The formula which showed the best in-vitro release was clinically tested. It was found that formulations containing Rifampicin in the form of solid dispersion with PEG have shown the best release characteristics of the antibiotic from oleaginous bases containing Tween 80. The clinical and bacterological data had confirmed the in vitro results and proved the superiority of the proposed formula to the conventional one.
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