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Abstract
The standard of care for newly diagnosed advanced ovarian cancer (NADOC) is represented by surgical debulking followed by systemic platinum–taxanes combination chemotherapy. At the last European Society for Medical Oncology (ESMO) Congress, results from three trials testing three different poly-adenosine-diphosphate-ribose-polymerase (PARP) inhibitors (olaparib, niraparib, veliparib) in first-line therapy of OC have been presented. For the first time, these studies evaluated the efficacy of PARP inhibitors in this setting and the relative predictive biomarkers for patients' selection. The use of a PARP inhibitor is related with prolonged progression free survival (PFS) in the whole population of NADOC, although the magnitude of benefit varies widely among subgroups, highlighting the need to identify specific biological subtypes into clinical practice. In this minireview, we discuss the updated data available from clinical studies in this scenario.
Highlights
The standard of care for newly diagnosed advanced ovarian cancer (NADOC) is represented by surgical debulking followed by systemic platinum–taxanes combination chemotherapy.The addition of bevacizumab to first-line chemotherapy improves progression free survival (PFS) in patients with higher risk of recurrence (International Federation of Gynecology and Obstetrics FIGO stage IV or suboptimally debulked stage III ovarian cancer—OC)
The SOLO-1 trial was the first trial evaluating the efficacy of maintenance therapy with the PARP inhibitor olaparib in patients with NADOC with a germline or somatic mutation in BRCA1/2, who responded to platinum-based chemotherapy [1]
The PFS benefit observed with olaparib plus bevacizumab in patients with BRCA-mutated tumors (HR = 0.31; 95% CI 0.20–0.47) in the PAOLA-1 study was consistent with the results reported in the SOLO-1 trial (HR = 0.30; 95% CI, 0.23–0.41)
Summary
These studies evaluated the efficacy of PARP inhibitors in this setting and the relative predictive biomarkers for patients’ selection. The use of a PARP inhibitor is related with prolonged progression free survival (PFS) in the whole population of NADOC, the magnitude of benefit varies widely among subgroups, highlighting the need to identify specific biological subtypes into clinical practice. In this minireview, we discuss the updated data available from clinical studies in this scenario
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