Abstract
Colorectal cancer stem cells (CSCs) are a subset of cancer cells capable of tumor initiation and maintenance. Colorectal CSCs are also relatively resistant to 5-flurouracil and failure to kill this cell population contributes to tumor persistence or recurrence. CSC chemoresistance is at least partially controlled by enhanced DNA damage repair mechanisms. One such mechanism is regulated by poly(ADP-ribose) polymerase (PARP). Inhibition of PARP decreases the ability to repair DNA damage and leads to increased cancer cell death.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
