Paroxysmal atrial fibrillation prediction based on morphological variant P-wave analysis with wideband ECG and deep learning

Abstract

Background and objectiveAtrial fibrillation (AF) is one of the most frequent asymptomatic arrhythmias associated with significant morbidity and mortality. Identifying the susceptibility to AF based on routine or continuous ECG recording is of considerable interest. Despite several P-wave characteristics and skin sympathetic nerve activity (SKNA) linked to AF onset, neither factor has offered accurate predictability. We propose a deep learning enabled method for AF risk prediction. MethodsWe develop a novel MVPNet to predict the upcoming onset of paroxysmal AF. MVPNet combines wavelet-based feature extraction and a deep learning classifier. MVPNet detect the approaching of AF onset by analyzing the template and frequency in P-wave segments. The morphological variant P-wave (MVP) analysis includes P-wave and SKNA features cross temporal-spectral domain. Subsequently, we designed an optimized lightweight convolutional neural network model to detect the MVP features of pre-AF episodes during sinus rhythm segments. Wideband ECG data obtained through the neuECG protocol from eight PAF patients with 177 times AF occurrence in this study. We compared the accuracy of AF prediction between ordinary ECG and neuECG. ResultsThe MVPNet effectively predicted the onset of AF episodes. 89% of ECG recorded at 5 min before the AF onset can be identified using neuECG. The proposed deep learning model, MVPNet, obtained a better precision and inference speed with less computing resources than existing models. The gradient activation map showed that neuECG recording may be a superior AF risk predictor. ConclusionsMVP analysis combined SKNA and P-wave parameters to improve predictive accuracy. The proposed MVPNet based on neuECG is superior to existing AF risk assessment with improved reliability and effectiveness. The method can be potentially applied in clinical scenarios for real-time, continuous AF prediction.