Abstract
e16002 Background: To evaluate patients with parotid squamous cell carcinoma (SCC) to see is it a primary or metastatic and determine the outcome of patients. Methods: Fifty-nine patients were identified with parotid SCC through the hospital database, patients’ charts, imaging studies, and computerized notes of the University of Michigan. Results: Fifty patients diagnosed as metastatic SCC of parotid lymph nodes. However, 9 patients diagnosed as primary. Forty seven patients with metastatic SCC treated with surgery and post-operative radiotherapy. The median follow up of these patients was 33 months. The 3-year actuarial cause specific survival was 91%. The 3-year actuarial local recurrence free survival (LRFS) and disease free survival rate were79% and 77% respectively. Positive surgical margin after parotidectomy was the only factor that had statistically significant poor LRFS. Conclusions: The most common site of the primary tumor was a cutaneous SCC of the face. All patients should be considered for facial sparing radical parotidectomy and adjuvant radiotherapy. Neck dissection or elective neck irradiation for ipsilateral neck is recommended due to high occult LN metastasis. The addition of chemotherapy or targeted therapy may be beneficial and are points of research. Patients’ characteristics. Metastatic SCC (50) No. (%) Primary SCC (9) No. (%) Clinical neck L.N Facial palsy Neck dissection Facial preservation Positive margins PNI Grade of disease Pathologic neck L.N Occult neck L.N spread Neck L.N. ECE Parotid RT Ipsilateral neck RT Bilateral neck RT Chemotherapy Local recurrence Neck recurrence Distant metastasis Cause specific death 8 (16) 2 (3) 44 (88) 34 (68) 19 (38) 13 (26) GI 6 (12) GII 30 (60) GIII 14 (28) 24 /44 (54) 16/36 (44) 9/24 (37) 47 (94) 42 (84) 2 13 (26) 11 (22) 0 2 (Lung) 4 3 (33) 1 (11) 7 (77) 3 (33) 3 (33) 4 (44) GI 2 (22) GII 2 (22) GIII 5 (56) 3/7 (42) 0/4 2/3 (66) 9 (100) 8 (88) 1 4 (44) 0 0 1 (Lung) 0 Abbreviations: SCC: squamous cell carcinoma; L.N: lymph node; PNI: perineural invasion; ECE: extracapsular extension; RT: radiotherapy.
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