Abstract
Background: Parkinson’s is a neurodegenerative and progressive disease, with an unknown origin that can lead to functional incapacity and decreased quality of life. Objectives: Analyze the number of hospital admissions for Parkinson’s Disease in the Southeast of Brazil. Design and setting: Transversal, descriptive Epidemiologic study between the years of 2011 and 2020 in the Southeast of Brazil. Methods: Study realized using data from the Department of Information of the Brazilian Health System (DATASUS). The variables researched were hospital admissions, age, and year. Results: In the Southeast region, in the determined period, there was an average of 405 hospital admissions per year, an average growth of 4% between the years of 2011 and 2019. However, in 2020, there was a 30% decrease compared to the previous year. It was also observed that in the gap ages between 40 to 49 and 50 to 59 years old, there was a significant increase in the number of hospital admissions. In addition, the age gap between 50 to 80 or more represents an average of 90.88% of all the hospital admissions of the last decade. Conclusion: In the Southeast of Brazil, Parkinson’s Disease had a noticeable absolute reduction of the total admissions analyzed in the last year and a deviation in the average growth of the other years, meaning a possible relation with the COVID-19 pandemic.
Highlights
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack
The present review study aimed to address the mechanisms of action of capsaicin and other chemical inducers in mast cell degranulation and an interaction of nerves and events that happen in the dura mater with the activation of mast cells
Conclusion: the analyzed data indicate that the polymorphisms contributed to the susceptibility to Parkinson’s disease (PD), further studies related to the polymorphisms and their relationship to PD are still needed for more ethnic groups, and early diagnosis is possible
Summary
Capsaicin is able to induce mast cell degranulation, an event probably related to the pathophysiology of a migraine attack. Methods: A literature review and an observational, descriptive and transversal data collect on treatment for acute demyelinating polyradiculoneuritis, available at DATASUS from January 2008 to December 2020, and articles available at Scielo and PubMed. Results: There were 7,917 hospitalizations, representing a total expenditure of R$ 9,392,552.04, 2009 being the year with the highest number of hospitalizations (809) and 2017 with the highest amount spent during the period (R$ 967,284.65). Methods: A literature review and an observational, descriptive and transversal data collect on surgical treatment was carried out, available from January 2008 to December 2020 and articles available in Scielo, Lilacs and PubMed. Results: There were 15,148 hospitalizations for surgical procedures for the treatment of chronic subdural hematoma, representing a total expenditure of R$ 45,365,258.21, with 2018 being the year with the highest number of hospitalizations (1,418) and with the highest amount spent during the period (R$ 4,570,334.28). Conclusions: The “Coca-Cola Bottle sign” is a classic sign of Graves’ disease, some signs, such as, unilateral and single orbital musculature involvement, may be suggestive of involvement by other etiologies, suggesting the benefit of an early expanded investigation
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