Abstract
Long non-coding RNAs (lncRNAs) have been recently reported to be involved in the pathoetiology of Parkinson’s disease (PD). Circulatory levels of lncRNAs might be used as markers for PD. In the present work, we measured expression levels of HULC, PVT1, MEG3, SPRY4-IT1, LINC-ROR and DSCAM-AS1 lncRNAs in the circulation of patients with PD versus healthy controls. Expression of HULC was lower in total patients compared with total controls (Expression ratio (ER)=0.19, adjusted P value<0.0001) as well as in female patients compared with female controls (ER=0.071, adjusted P value=0.0004). Expression of PVT1 was lower in total patients compared with total controls (ER=0.55, adjusted P value=0.0124). Expression of DSCAM-AS1 was higher in total patients compared with total controls (ER=5.67, P value=0.0029) and in male patients compared with male controls (ER=9.526, adjusted P value=0.0024). Expression of SPRY4-IT was higher in total patients compared with total controls (ER=2.64, adjusted P value<0.02) and in male patients compared with male controls (ER=3.43, P value<0.03). Expression of LINC-ROR was higher in total patients compared with total controls (ER=10.36, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=4.57, adjusted P value=0.03 and ER=23.47, adjusted P value=0.0019, respectively). Finally, expression of MEG3 was higher in total patients compared with total controls (ER=13.94, adjusted P value<0.0001) and in both male and female patients compared with sex-matched controls (ER=8.60, adjusted P value<0.004 and ER=22.58, adjusted P value<0.0085, respectively). ROC curve analysis revealed that MEG3 and LINC-ROR have diagnostic power of 0.77 and 0.73, respectively. Other lncRNAs had AUC values less than 0.7. Expression of none of lncRNAs was correlated with age of patients, disease duration, disease stage, MMSE or UPDRS. The current study provides further evidence for dysregulation of lncRNAs in the circulation of PD patients.
Highlights
As a progressive neurodegenerative condition, Parkinson’s disease (PD) affects 2-3% of the whole population age more than 65 years with a gradually increasing incidence [1]
This long noncoding RNAs (lncRNAs) has a role in regulation of immune response, since up-regulation of HULC has been shown to has a necessary role in pro-inflammatory responses in the course of LPS-associated sepsis [23]
HULC has a role in regulation of apoptosis
Summary
As a progressive neurodegenerative condition, Parkinson’s disease (PD) affects 2-3% of the whole population age more than 65 years with a gradually increasing incidence [1] This disorder is characterized by resting tremor, bradykinesia, rigidity of muscles, balance disturbances, postural instability and a number of non-motor manifestations, cognitive dysfunction which affects the vast majority of PD patients [2]. A multi-disciplinary study of four highly conserved and brain-expressed lncRNA has shown that lncRNAs are functional transcripts with important roles in the development of vertebrate brain. This speculation is based on the observed preservation of lncRNAs across various amniotes, obvious conservation of their exons structures, and resemblances in lncRNA signature throughout the embryonic and early postnatal phases [5]
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