Abstract
Certain sequence variants of the α-synuclein gene are linked to the risk of Parkinson's disease. An analysis of these variants using gene-editing technology provides a possible explanation for this increased risk. See Letter p.95 Determining how genetic risk variants associated with complex diseases actually contribute to the pathological features of the disease remains a challenge. Non-coding sequences variants have been proposed to act in cis to modulate the expression of disease-linked genes, but it is difficult to test this hypothesis because of the complexity of the diseases linked to these variants. Rudolf Jaenisch and colleagues have developed a genetically controlled system to dissect out the cis-acting effect of allelic variants on the expression of the α-synuclein gene SCNA, which has been linked to Parkinson's disease development.
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