Abstract
Parity Associated with Long-Term Disease Progression in Women with Multiple Sclerosis
Highlights
Similar to other immune mediated diseases [1,2], pregnancy was shown to influence Multiple Sclerosis (MS) disease activity
Our results demonstrate that parous women with RRMS take a longer time to reach a well-defined disability milestone compared to nulliparous women, suggesting that pregnancy may convey a long term benefit
Further research is needed to determine why pregnancy might be protective against long term multiple sclerosis (MS) disability progression
Summary
Similar to other immune mediated diseases [1,2], pregnancy was shown to influence Multiple Sclerosis (MS) disease activity. It is marked by a decrease in relapse rate, especially during the third trimester. The protective effects of pregnancy on MS disease activity are thought in part to reflect the anti-inflammatory effects of sex hormones. Sex hormones such as estrogen and progesterone are increased during pregnancy, with the highest levels reported in the third trimester, and a sharp drop postpartum [7]. Because MS typically occurs during childbearing years, it is important to determine the long term effect of pregnancy
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