Abstract
ObjectiveThe association between parity and type 2 diabetes has been studied in developed countries and in Singapore and Chinese women but not in Hispanics. Herein we evaluated the association between parity (number of live births) with diabetes in a group of Hispanic postmenopausal women from Colombia.Research design and methodsHerein we evaluated the association between parity and diabetes in a population of 1,795 women from Colombia. Women were divided in birth categories (0 [referent], 1 or 2, 3–5, 6 or > births). Medical history of diabetes and anthropometric characteristics were recorded. Logistic regressions were performed in order to find the association between parity and diabetes in bivariable and multivariable models after controlling for age, body mass index (BMI), waist hip ratio (WHR) and diabetes family history, among other variables.ResultsIn our study, there was an association between parity and diabetes after adjusting for age, BMI and diabetes family history in the multiparous women groups when compared to the women with no births (Referent group) [1–2 births vs. referent OR 5.2 (95 CI 1.2–22.9), 3–5 births vs. referent OR 5.5 (1.3–23.0) and ≥6 births vs. referent OR 7.5 (1.8–31.8), respectively]. The association was maintained in two of the groups in the multivariable analysis [OR 5.0 (1.1–22.9) and 5.3 (1.2–23.5)], for 1 or 2 births and 6 or > births versus 0 births, respectively. Positive diabetes family history and WHR were also associated with an increased risk of diabetes [OR 4.6 (3.0–7.0) and 4.1 (2.0–8.1), respectively].ConclusionsIn postmenopausal Hispanic women, multiparity, as well as a positive family history of diabetes and a high waist-hip ratio were associated with higher diabetes risk.
Highlights
In our study, there was an association between parity and diabetes after adjusting for age, body mass index (BMI) and diabetes family history in the multiparous women groups when compared to the women with no births (Referent group) [1–2 births vs. referent OR 5.2 (95 CI 1.2–22.9), 3–5 births vs. referent OR 5.5 (1.3–23.0) and ≥6 births vs. referent OR 7.5 (1.8–31.8), respectively]
Positive diabetes family history and waist hip ratio (WHR) were associated with an increased risk of diabetes [OR 4.6 (3.0–7.0) and 4.1 (2.0–8.1), respectively]
In postmenopausal Hispanic women, multiparity, as well as a positive family history of diabetes and a high waist-hip ratio were associated with higher diabetes risk
Summary
During each pregnancy there are known physiological changes, including: insulin resistance, fat accumulation, dyslipidemia, and inflammation [1,2,3,4,5,6] that could have an impact on the risk of diabetes and other cardio-metabolic disorders later in life.In multiparous women, the aforementioned physiological changes occurring during each gestation may have lasting effects in the health of the mother which could transcend beyond the gestational period and increase the risk of metabolic syndrome, diabetes and cardiovascular disease later in life [7-12].Currently there is evidence suggesting an association between childbearing and the risk of type 2 diabetes in women in populations in both developed and developing countries [9-12] in some cases this association has been lost after controlling for confounding variables such as age and obesity [13]. During each pregnancy there are known physiological changes, including: insulin resistance, fat accumulation, dyslipidemia, and inflammation [1,2,3,4,5,6] that could have an impact on the risk of diabetes and other cardio-metabolic disorders later in life. In addition pregnancy is associated with significant weight retention (when the woman is not able to return to the original pre-pregnancy weight). This can increase their post pregnancy BMI after each delivery increasing the risk of type 2 diabetes later in life
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
