Abstract
Methods: A population-based sampling strategy was used to recruit children aged 5-12 years with a history of four or more episodes of acute asthma in the preceding year. Episodes of acute asthma, rather than participants, were randomised to receive a short course of parent-initiated prednisolone (1mg/kg/day) or placebo. Parents initiated a course of treatment if they felt, from previous experience, the episode to be a more severe attack, or if the symptoms were not improving after 6 to 8 hours with regular use of reliever medication. The primary end point: a validated 7-day daytime symptom score (DTSS). Other end points: a validated 7-night night time symptom score (NTSS), health resource utilisation (HRU), and school absenteeism.
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