Abstract
Introduction: Parenteral nutrition (PN) with lack of enteral stimulation exerts detrimental effects on the mucosal immune system and increases patient risk of infection. The main strategic, mucosal defense molecule is immunoglobulin A (IgA), which decreases with PN. IgA is produced via a complex interaction of T and B cells in the lamina propria (LP) after antigen programming in gut Peyer's patches (PP). Our previous work shows a 50% reduction in overall lymphocyte numbers in LP & PP with PN, but this accounted for only half of the reduction in IgA.
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