Parenteral Denaturization of Foreign Proteins

Abstract

Summary and Conclusions The rate of parenteral denaturization of horse proteins in horse serum immune dogs, therefore, is distinctly slower than the rate in normal dogs. There is not the rapid denaturization previously observed in hypersensitive dogs, all tests with hypersensitive donors being negative after the eighteenth hour (1). Nor is there the still more rapid denaturization one would predict from the unitarian conception of the relation of anaphylaxis to immunity. The biochemical properties or relationships responsible for rapid protein denaturization in hypersensitive dogs are apparently wholly absent or inoperative in immune dogs. This finding is consistent with our previous conclusion of the non-identity of specific antibodies in hypersensitive and immune dogs (3).