Abstract
The prevalence of allergic diseases in children is markedly increasing to epidemic proportions. The aim of this study is to describe the presence and examine associated parental and child characteristics of allergic sensitization and physician-diagnosed allergy in Dutch children at age 10 years. This study among 5471 children was performed in a population-based prospective cohort from fetal life onwards. Allergic sensitization was measured by skin prick tests. Physician-diagnosed allergy and parental and child characteristics were collected by questionnaires. In children aged 10 years, inhalant and food allergic sensitization was present in 32.2% and 7.1%, and physician-diagnosed inhalant and food allergy in 12.4% and 2.3%. Maternal and paternal history of allergy, eczema or asthma was associated with increased risks of physician-diagnosed inhalant allergy (aOR (95% CI) 1.44 (1.23–1.70) and 1.59 (1.30–1.94), respectively), but not with food allergy. Asthma and eczema ever at age 10 years were associated with increased risks of physician-diagnosed inhalant allergy (4.60 (3.55–5.96) and 2.42 (1.94–3.03), respectively). Eczema ever at age 10 years was associated with an increased risk of physician-diagnosed food allergy (5.78, 3.04–9.52), with the highest risk of cashew (7.36, 3.20–16.94) and peanut (5.58, 3.08–10.10) food allergy.Conclusions: We found strong effects of parental history of allergy, eczema or asthma on the presence of physician-diagnosed inhalant allergy in children at age 10 years. Eczema ever at age 10 years was a strong risk factor for the development of physician-diagnosed inhalant and food allergy.What is Known:• The prevalence of allergic diseases in children has markedly increased.• Early-life influences are critically important in the development of allergic diseases.What is New:• Maternal and paternal history of allergy, eczema or asthma is associated with increased risks of physician-diagnosed inhalant allergy but not with food allergy.• Eczema ever at age 10 years is associated with an increased risk of physician-diagnosed food allergy, with the highest risk for cashew and peanut food allergy.
Highlights
The prevalence of allergic diseases, including inhalant and food allergies, in children has markedly increased to epidemic proportions [25, 29], for which the reasons are not fully clear
Maternal and paternal history of allergy, eczema or asthma is associated with increased risks of physician-diagnosed inhalant allergy but not with food allergy
Eczema ever at age 10 years is associated with an increased risk of physician-diagnosed food allergy, with the highest risk for cashew and peanut food allergy
Summary
The prevalence of allergic diseases, including inhalant and food allergies, in children has markedly increased to epidemic proportions [25, 29], for which the reasons are not fully clear. Allergic diseases have great social and economic impact both on individuals and their family members [25]. A recent register-based study in Danish and Swedish children showed that the lifetime prevalence at age 10 years of asthma and allergic rhinitis was 15.6% and 20.4%, respectively [15]. Results from the PASTURE cohort study showed a distinct group of children with severe atopy characterized by high specific immunoglobulin E (IgE) levels and a strong propensity for asthma, hay fever, eczema and impaired lung function [16]. A recent review on European children until age 17 reported a prevalence of symptoms combined with allergic sensitization to at least one allergen of 3.6% [23]
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